Rnai Clinical Studies

RNA Interference - Wikipedia, The Free Encyclopedia
Other proposed clinical uses center on antiviral therapies, including topical microbicide treatments that use RNAi to treat infection (at Harvard Medical School; Despite the proliferation of promising cell culture studies for RNAi-based drugs, ... Read Article

Advanced Drug Delivery Reviews
Undergoing clinical trials, Recent studies have provided insights into the molecular mechan-isms of RNAi, in which dsRNA induces the silencing of homologous mRNA. discovery of the RNAi mechanism [16]. Most siRNAs in clinical trials ... Read Here

Infl Ammation-Free ShRNA Expression Vectors For Cystic ...
When administered in vivo in pre-clinical and clinical studies1. 4We have recently developed CpG-free pDNA vectors for the treatment of Cystic Fibrosis (CF) lung disease. 4pGM205 directs robust in vitro RNAi following co-transfection of the ... Retrieve Document

Insight Review Articles Unlocking The Potential Of The Human ...
For RNAi-based studies of gene function. Ultimately, caveats in the clinical trial for HIV treatment is expected to take place in the next year or two. RNAi to treat viral hepatitis Hepatitis induced by the hepatitis B virus (HBV) and by HCV is a ... Read More

Arrowhead Announces Pricing Of A Public Offering Of Common Stock And Warrants
Arrowhead Research Corporation today announced that it has priced a public offering of approximately 1.8 million units at a price to the public of $2.26 per unit. The Company has received commitments and indications for approximately $4 million in gross proceeds. ... Read News

Pre-clinical ELN Solutions - YouTube
7:25 Lou Gehrig's Disease: Stem Cell Therapy Pre-Clinical Studies by CIRMTV 319 views; 46:49 Pre-Clinical Endodontics - single rooted tooth by UMichDent 5,580 views; 10:30 RNAi Therapeutics and Cancer Treatment by SilenceTherapeutics 648 views; ... View Video

RNA OLIGONUCLEOTIDES: EMERGING CLINICAL APPLICATIONS NATIONAL ...
8:30 AM Keynote Address- Overview of RNAi and microRNAs Presenter: Phillip Sharp, Ph.D., Pharmacokinetic studies Presenters: John Rossi, Ph.D., Beckman Research Institute of the the clinical application of miRNAs and what may be the key differences? ... Content Retrieval

Cardiac-targeted RNA Interference Mediated By An AAV9 Vector ...
RNAi-based protocols with possible clinical potential could be based on viral vectors with appropriate organ targeting. With respect to the treatment of cardiac diseases, From clinical studies, it is known, however, that during acute cardiac ... Fetch This Document

Content And Format Of An Investigational Device Exemption ...
Phases of Device Studies. The clinical investigation of the safety and/or effectiveness of a non-approved device is typically divided into two phases, Feasibility Studies and Pivotal Studies. ... Return Doc

THE LUSTGARTEN FOUNDATION FORMS NATIONAL PANCREATIC CANCER ...
The research will combine comprehensive RNAi screening with pre-clinical studies in mouse models to identify genetic vulnerabilities in pancreatic cancer cells, making them promising targets for drug therapy. -- more -- ... Visit Document

Should You Take Your Thyroid Medication At Night? Taking ...
Several studies are now showing that taking thyroid drugs like levothyroxine at bedtime may help improve absorption of thyroid medication and ease symptoms. Thyroid patient advocate Mary Shomon explores the issue. In 2007, Clinical Endocrinology reported on a small pilot study, ... Read Article

Evidence Of RNAi In Humans From Systemically Administered ...
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles conducting the first in-human phase I clinical trial involving the Although there are animal studies that do support the possibility ... Get Document

Team Develops Safe, Effective RNA Interference Technique
(RNAi) as a way to turn off specific disease-causing genes. Despite this test the delivery materials in human clinical trials within the next few years. In previous studies, lipids (fat-soluble molecules such as fats, waxes and cholesterol) ... View Full Source

RNAi Screening Of The Tyrosine Kinome Identifies Therapeutic ...
RNAi technology to directly assess and compare the effect of individually targeting each Previous studies have shown that phosphorylation of signal with clinical response to gefitinib therapy. Science. 2004;304:1497-1500. 4. Smith I, ... Fetch This Document

Arrowhead Research Corporation Announces Proposed Public Offering Of Common Stock And Warrants
Arrowhead Research Corporation today announced that it intends to offer units consisting of shares of common stock and warrants in a public offering. Dawson James Securities, Inc. ... Read News

For More Information, Contact
Successful mouse studies and could bring RNAi-based therapy one step closer to human clinical trials. noteworthy advances in clinical and basic research. The Medical School attracts more than $255 million in research funding annually, ... Visit Document

Molecular Consequences Of Silencing Mutant K- Ras In ...
Preventing tumor growth in animals (10-12), clinical studies using antisense DNA oligonucleotides against ras have not entered large clinical trials (13, 14). One major problem in RNAi disrupts the malignant phenotype of pancreatic adeno- ... Fetch Full Source

Exploring The World Of RNA Interference In Plant Functional ...
Therapeutically, and clinical trials to test this possibility are already being planned (7, 18 ). and limitations when is used in functional genomics studies. An advantage of using RNAi is that a specific gene can be silenced if the target sequence is better chosen. ... Read Content

What Is C-Reactive Protein (CRP)?
New studies indicate CRP may be elevated in heart attacks. It is yet to be determined if CRP serves as a marker of heart disease or whether it plays a part in causing atherosclerotic disease (hardening of the arteries). ... Read Article

YouTube - RNA Interference - YouTube
Dr. Klaus Giese, Chief Scientific Officer of Silence Therapeutics, presents at the German Science Day on 'The Pre-Clinical and Clinical LI-COR Bisociences Learn how infrared fluorescent Western Blots and In-Cell Western Assays can be used in RNAi studies. Monitor RNAi knockdo ... View Video

Computational Genomic Screening For SiRNA Knockouts
Was that the number and size of clinical studies would be reduced by the ability to Fuchs, F. et al. 2010. Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Molecular Systems Biology 6:370 Case Studies; Drug Development; GMOs and Food Biotech; ... Read Article

Pharmaceutical Approvals F-D-C EPORTS
2006: Merck acquires Sirna, one of the first companies to bring RNAi therapy into clinical trials with Sirna027. “Previous studies had demonstrated that certain combinations of siRNAs activate the cell’s innate immune response. Since ... View Document

The National Cancer Institute At Frederick
53 clinical research studies throughout the United States and abroad. CTM ensures that patients’ rights and well-being are protected; Expertise in RNAi Gene Silencing Another new technology in which GEL is gaining expertise is RNAi gene silencing. ... Retrieve Full Source

RXi Pharmaceuticals Falls 14% After Choosing 1st RNAi ...
Including scar formation. sd-rxRNA compounds are RNAi-based therapeutics that have demonstrated efficient cellular uptake without a delivery vehicle in preclinical studies, clinical; study; License: Standard YouTube License 3 likes, 0 dislikes Show more . ... View Video

Improvements In Transfection Efficiency And Tests Of RNA ...
Of leishmaniasis, whose clinical manifestations range from cutaneous skin lesions to the deadly visceral form. For the RNAi studies, the use of transient transfections approaches guards against po-tential problems accompanying stable transfections, which ... Access This Document

Dynamic Polyconjugates (DPC) Technology: An Elegant Solution ...
RNAi is poised to be a transformative technology in the pharmaceutical industry. Pre-clinical studies using non-human primates reveal that DPCs are highly efficacious for delivery to liver with safety margins beyond those currently ... Access Full Source

Marina Biotech, Inc. Announces Year-to-Date 2012 Financial Results
Marina Biotech, Inc. , a leading RNAi-based drug discovery and development company, yesterday reported financial results for the nine months ended September 30, 2012, and provided an update on 2012 corporate ... Read News