Synvisc Clinical Studies

SUMMARY OF SAFETY AND EFEFCTIVENESS DATA (SSED) I. GENERAL ...
Joint infections did not occur in any of the clinical studies of Synvisc or Synvisc-One and have been reported only rarely during clinical use of Synvisc. Adverse Events Outside of the Target Knee. Overall 101 patients (Synvisc-One: n=47, 38.2%; PBS Control: n=54, 41.5%) experienced at ... Read More

Osteoarthritis Treatments - 25 Effective Osteoarthritis ...
The clinical expertise of the committee members helped formulate the SOR too, including such factors as their perception of patient tolerance for the treatment. The SOR is expressed as a percentage that represents the committee's consensus that the treatment is actually effective. ... Read Article

I. Background
Clinical studies include local symptoms such as pain, knee swelling, rash and itching at the injection site. The treatment appeared to be well tolerated and For Synvisc, a standard three-injection course costs approximately $500. For Hyalgan, ... Fetch Doc

Hyaluronic Acid Viscosupplementation And Osteoarthritis
These include Synvisc (Genzyme Corp, Cambridge, Massachusetts), Hyalgan (Sanofi-Sythelabo Clinical studies have demonstrated that HA viscosupple-mentation is generally well tolerated.5 Although signifi-cant complications are rare, ... Get Doc

Patient Guide Are There Any Side Effects? To Synvisc Treatment
Extensive clinical studies have shown Synvisc to be highly effective. In knee studies, over 80% of patients felt better or much better after their first course of Synvisc.5,8 symptoms? While Synvisc is a highly effective treatment, Synvisc ... Retrieve Doc

POA Black Format W/Instructions
Clinical Data SYNVISC® vs. Saline Control SYNVISC® vs. Saline Three injections, 20:410-423. 2Adams ME. An analysis of clinical studies of the use of crosslinked hyaluronan, hylan, in the treatment of osteoarthritis. J Rheumatol. 1993;20(suppl 39):16-18. ... Document Retrieval

Consumer Brochure E - Genzyme
Laboratory and clinical studies proved that Synvisc does not cause general harmful reactions. Does that mean Synvisc is safer than other medications my physician might prescribe? Synvisc is safer than other medications because it is not a medication! ... Return Doc

VISCOSUPPLEMENTATION For Osteoarthritis Of The Knee:
Retreatment Euflexxa® Hyalgan® Orthovisc® Supartz® Synvisc® Clinical Studies N/A 6 Studies (1-RCT, 1-OL, 3 case series, 1-retrospective) N/A N/A 8 studies (8-case series) Number of courses (from studies above) -- 2-8 -- -- ... Fetch This Document

Ehlers–Danlos Syndrome - Wikipedia, The Free Encyclopedia
The Beighton scale is widely used to assess the degree of joint hypermobility. Both DNA and biochemical studies can be used to help identify affected individuals The lack of clinical distinction between the hypermobility type of Ehlers–Danlos syndrome and the joint hypermobility ... Read Article

PATIENT INFORMATION - Synvisc-One® Official Site ...
What did the clinical studies show? A study was conducted in 6 countries outside the United States with 21 physicians. that occurred during the clinical trial of Synvisc-One: •Pain in the knee or at the injection site •Stiffness, ... Get Content Here

A New Generation Of Viscosupplements
1997 when Synvisc®(hylan G-F 20) and Hyalgan® were approved as medical devices by the Food and Drug Numerous clinical studies show that at 6-month follow-up, exogenous HA injection provided superiorpain relief and functional improvement ... Return Document

United Kingdom - Wikipedia, The Free Encyclopedia
In 2006 a report by the Surveillance Studies Network found that the UK had the highest level of mass surveillance among industrialised western nations. Foreign relations. Main article: Foreign relations of the United Kingdom. ... Read Article

Assessment Of Immunologic Mechanisms For Flare Reactions To ...
Reactions to Synvisc Andrew A. Marino, PhD; David D. Waddell, MD; In case reports and retrospective studies, flares were described in 22 patients treated with Syn- Clinical Data for the Three Groups of Patients Studied Using ELISA ... Retrieve Here

Health Plan Coverage Policy - Welcome To ARBenefits
Synvisc, Synvisc One, Hyalgan, Supartz, Euflexxa and Orthovisc are covered in the treatment of knee arthritis only. Clinical studies have demonstrated that injection of these agents into the joint space of osteoarthritic knees may be followed by significant reduction in pain ... Return Document

Table Of Contents - U S Food And Drug Administration Home Page
Been reported only rarely during clinical use of Synvisc. 1.8.2 Adverse Events Outside of the Target Knee Overall 101 patients (Synvisc-One: n=47, 38.2%; Placebo: n=54, 41.5%) experienced at 1.12 CONCLUSIONS DRAWN FROM THE STUDIES This double-blind, ... Access Content

DRA FT - U S Food And Drug Administration Home Page
124 What did the clinical studies show? 125 A study was conducted in 6 countries outside the United States with 21 physicians. The 197 of the clinical trials of Synvisc or Synvisc-One and have been reported only rarely during clinical ... Document Viewer

SYNVISC PACKAGING INSERT - Genzyme In The UK
In vitro studies have shown that Synvisc protects cartilage cells against certain physical and chemical damage. Clinical benefit from the treatment may still be apparent after such reactions. Intra-articular infections did not occur in any of ... Retrieve Doc

HYALURONIC ACID DERIVATIVES EUFLEXXA® (sodium Hyaluronate ...
Hyaluronic Acid Derivatives Clinical Rationale Revised 05/24/2011 Reviewed 05/24 Evidence submitted to the FDA regarding repeat treatment consisted of two studies. Guidance from the National Institute for Health and Clinical Excellence SYNVISC® (hylan G-F 20) / SYNVISC-ONE® ... Fetch Content

(Synvisc
The clinical signs and symptoms of OA include joint pain, morning stiffness, loss of functioning, In these studies hylan G-F 20 was administered byintra-articular injection once-weekly for 3 weeks. Biomatrix, Inc. Synvisc Package Insert. 1999. 2. Balint G,.Szebenyi B. Diagnosis of ... View Full Source

Current Synvisc-One Package Insert - U S Food And Drug ...
Injections in seven clinical trials of Synvisc. There were 39 reports in 37 patients (2.2% of injections, 7.2% of patients) of knee pain CLINICAL STUDIES The safety and effectiveness of Synvisc were studied in patients ≥40 ... Return Doc

Clinical Medicine Insights: Arthritis And Musculoskeletal ...
Tify all studies relating to the use of Synvisc report of a task force of the Standing Committee for International Clinical Studies including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2000;59: 936–44. 12. ... Read More

May Occur After Intra-articular Injection Of SYNVISC. In Some
1771 injections in seven clinical trials of SYNVISC. There were 39 reports in 37 patients (2.2% of injections, 7.2% of patients) of knee pain and/or swelling after these injections. – What adverse events were observed in the clinical studies? ... View Document

Synvisc®/Synvisc-One® (hylan G-F 20) - Regence
- Hyaluronic acids have not been proven in reliable clinical studies to be more effective than non-pharmacologic or generic analgesics such as acetaminophen and NSAIDs. Synvisc or Synvisc-One, for intra-articular injection, 1 mg . HCPCS : ... Access Document